HPV-FASTER: broadening the scope for prevention of HPV-related cancer.
Identifieur interne : 001D84 ( Main/Exploration ); précédent : 001D83; suivant : 001D85HPV-FASTER: broadening the scope for prevention of HPV-related cancer.
Auteurs : F Xavier Bosch [Espagne] ; Claudia Robles [Espagne] ; Mireia Díaz [Espagne] ; Marc Arbyn [Belgique] ; Iacopo Baussano [France] ; Christine Clavel [France] ; Guglielmo Ronco [Italie] ; Joakim Dillner [Suède] ; Matti Lehtinen [Finlande] ; Karl-Ulrich Petry [Allemagne] ; Mario Poljak [Slovénie] ; Susanne K. Kjaer [Danemark] ; Chris J L M. Meijer [Pays-Bas] ; Suzanne M. Garland [Australie] ; Jorge Salmer N [Mexique] ; Xavier Castellsagué [Espagne] ; Laia Bruni [Espagne] ; Silvia De Sanjosé [Espagne] ; Jack Cuzick [Royaume-Uni]Source :
- Nature reviews. Clinical oncology [ 1759-4782 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Dépistage systématique (), Détection précoce de cancer (), Femelle, Humains, Infections à papillomavirus (), Jeune adulte, Papillomavirus humain de type 16 (immunologie), Papillomavirus humain de type 18 (immunologie), Sensibilité et spécificité, Tumeurs du col de l'utérus (), Tumeurs du col de l'utérus (diagnostic), Tumeurs du col de l'utérus (virologie), Vaccination (), Vaccination (tendances), Vaccins contre les papillomavirus (usage thérapeutique).
- MESH :
- diagnostic : Tumeurs du col de l'utérus.
- immunologie : Papillomavirus humain de type 16, Papillomavirus humain de type 18.
- tendances : Vaccination.
- usage thérapeutique : Vaccins contre les papillomavirus.
- virologie : Tumeurs du col de l'utérus.
- Adulte, Adulte d'âge moyen, Dépistage systématique, Détection précoce de cancer, Femelle, Humains, Infections à papillomavirus, Jeune adulte, Sensibilité et spécificité, Tumeurs du col de l'utérus, Vaccination.
English descriptors
- KwdEn :
- Adult, Early Detection of Cancer (methods), Female, Human papillomavirus 16 (immunology), Human papillomavirus 18 (immunology), Humans, Mass Screening (methods), Middle Aged, Papillomavirus Infections (complications), Papillomavirus Infections (prevention & control), Papillomavirus Vaccines (therapeutic use), Sensitivity and Specificity, Uterine Cervical Neoplasms (diagnosis), Uterine Cervical Neoplasms (prevention & control), Uterine Cervical Neoplasms (virology), Vaccination (methods), Vaccination (trends), Young Adult.
- MESH :
- chemical , therapeutic use : Papillomavirus Vaccines.
- complications : Papillomavirus Infections.
- diagnosis : Uterine Cervical Neoplasms.
- immunology : Human papillomavirus 16, Human papillomavirus 18.
- methods : Early Detection of Cancer, Mass Screening, Vaccination.
- prevention & control : Papillomavirus Infections, Uterine Cervical Neoplasms.
- trends : Vaccination.
- virology : Uterine Cervical Neoplasms.
- Adult, Female, Humans, Middle Aged, Sensitivity and Specificity, Young Adult.
Abstract
Human papillomavirus (HPV)-related screening technologies and HPV vaccination offer enormous potential for cancer prevention, notably prevention of cervical cancer. The effectiveness of these approaches is, however, suboptimal owing to limited implementation of screening programmes and restricted indications for HPV vaccination. Trials of HPV vaccination in women aged up to 55 years have shown almost 90% protection from cervical precancer caused by HPV16/18 among HPV16/18-DNA-negative women. We propose extending routine vaccination programmes to women of up to 30 years of age (and to the 45-50-year age groups in some settings), paired with at least one HPV-screening test at age 30 years or older. Expanding the indications for HPV vaccination and much greater use of HPV testing in screening programmes has the potential to accelerate the decline in cervical cancer incidence. Such a combined protocol would represent an attractive approach for many health-care systems, in particular, countries in Central and Eastern Europe, Latin America, Asia, and some more-developed parts of Africa. The role of vaccination in women aged >30 years and the optimal number of HPV-screening tests required in vaccinated women remain important research issues. Cost-effectiveness models will help determine the optimal combination of HPV vaccination and screening in public health programmes, and to estimate the effects of such approaches in different populations.
DOI: 10.1038/nrclinonc.2015.146
PubMed: 26323382
Affiliations:
- Allemagne, Australie, Belgique, Danemark, Espagne, Finlande, France, Italie, Mexique, Pays-Bas, Royaume-Uni, Slovénie, Suède
- Angleterre, Auvergne-Rhône-Alpes, Catalogne, Champagne-Ardenne, Grand Est, Grand Londres, Hollande-Septentrionale, Hovedstaden, Piémont, Rhône-Alpes, Région de Bruxelles-Capitale, Svealand, Victoria (État)
- Amsterdam, Barcelone, Bruxelles, Copenhague, Londres, Lyon, Melbourne, Reims, Stockholm, Turin
- Université de Londres, Université de Melbourne
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 002A04
- to stream Ncbi, to step Curation: 002A04
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Le document en format XML
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y en Servicios de Salud, Instituto Mexicano del Seguro Social, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos</wicri:regionArea><wicri:noRegion>Morelos</wicri:noRegion></affiliation></author><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bruni, Laia" sort="Bruni, Laia" uniqKey="Bruni L" first="Laia" last="Bruni">Laia Bruni</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cuzick, Jack" sort="Cuzick, Jack" uniqKey="Cuzick J" first="Jack" last="Cuzick">Jack Cuzick</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno 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xml:lang="en">HPV-FASTER: broadening the scope for prevention of HPV-related cancer.</title><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Robles, Claudia" sort="Robles, Claudia" uniqKey="Robles C" first="Claudia" last="Robles">Claudia Robles</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Diaz, Mireia" sort="Diaz, Mireia" uniqKey="Diaz M" first="Mireia" last="Díaz">Mireia Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arbyn, Marc" sort="Arbyn, Marc" uniqKey="Arbyn M" first="Marc" last="Arbyn">Marc Arbyn</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Baussano, Iacopo" sort="Baussano, Iacopo" uniqKey="Baussano I" first="Iacopo" last="Baussano">Iacopo Baussano</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Clavel, Christine" sort="Clavel, Christine" uniqKey="Clavel C" first="Christine" last="Clavel">Christine Clavel</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire (CHU) Reims, Université de Reims Champagne-Ardenne and Institut National de la Santé et de la Recherche Médicale UMR-S 903, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU) Reims, Université de Reims Champagne-Ardenne and Institut National de la Santé et de la Recherche Médicale UMR-S 903, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Ronco, Guglielmo" sort="Ronco, Guglielmo" uniqKey="Ronco G" first="Guglielmo" last="Ronco">Guglielmo Ronco</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Cancer Epidemiology, Centre for Cancer Prevention (CPO), Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, Centre for Cancer Prevention (CPO), Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dillner, Joakim" sort="Dillner, Joakim" uniqKey="Dillner J" first="Joakim" last="Dillner">Joakim Dillner</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Laboratory Medicine, Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Departments of Laboratory Medicine, Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:affiliation>University of Tampere, School of Health Sciences, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Health Sciences, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Petry, Karl Ulrich" sort="Petry, Karl Ulrich" uniqKey="Petry K" first="Karl-Ulrich" last="Petry">Karl-Ulrich Petry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, Klinikum Wolfsburg, Wolfsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Klinikum Wolfsburg, Wolfsburg</wicri:regionArea><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion></affiliation></author><author><name sortKey="Poljak, Mario" sort="Poljak, Mario" uniqKey="Poljak M" first="Mario" last="Poljak">Mario Poljak</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Kjaer, Susanne K" sort="Kjaer, Susanne K" uniqKey="Kjaer S" first="Susanne K" last="Kjaer">Susanne K. Kjaer</name><affiliation wicri:level="3"><nlm:affiliation>Virus, Lifestyle &Genes, Danish Cancer Society Research Centre; and Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Virus, Lifestyle &Genes, Danish Cancer Society Research Centre; and Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Meijer, Chris J L M" sort="Meijer, Chris J L M" uniqKey="Meijer C" first="Chris J L M" last="Meijer">Chris J L M. Meijer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Centre (VUmc), Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Centre (VUmc), Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital; Murdoch Childrens Research Institute; and Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital; Murdoch Childrens Research Institute; and Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Salmer N, Jorge" sort="Salmer N, Jorge" uniqKey="Salmer N J" first="Jorge" last="Salmer N">Jorge Salmer N</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos</wicri:regionArea><wicri:noRegion>Morelos</wicri:noRegion></affiliation></author><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bruni, Laia" sort="Bruni, Laia" uniqKey="Bruni L" first="Laia" last="Bruni">Laia Bruni</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d' Oncologia-Catalan Institute of Oncology, IDIBELL, Avenida Gran Via 199-203, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cuzick, Jack" sort="Cuzick, Jack" uniqKey="Cuzick J" first="Jack" last="Cuzick">Jack Cuzick</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j">Nature reviews. Clinical oncology</title><idno type="eISSN">1759-4782</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Early Detection of Cancer (methods)</term><term>Female</term><term>Human papillomavirus 16 (immunology)</term><term>Human papillomavirus 18 (immunology)</term><term>Humans</term><term>Mass Screening (methods)</term><term>Middle Aged</term><term>Papillomavirus Infections (complications)</term><term>Papillomavirus Infections (prevention & control)</term><term>Papillomavirus Vaccines (therapeutic use)</term><term>Sensitivity and Specificity</term><term>Uterine Cervical Neoplasms (diagnosis)</term><term>Uterine Cervical Neoplasms (prevention & control)</term><term>Uterine Cervical Neoplasms (virology)</term><term>Vaccination (methods)</term><term>Vaccination (trends)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dépistage systématique ()</term><term>Détection précoce de cancer ()</term><term>Femelle</term><term>Humains</term><term>Infections à papillomavirus ()</term><term>Jeune adulte</term><term>Papillomavirus humain de type 16 (immunologie)</term><term>Papillomavirus humain de type 18 (immunologie)</term><term>Sensibilité et spécificité</term><term>Tumeurs du col de l'utérus ()</term><term>Tumeurs du col de l'utérus (diagnostic)</term><term>Tumeurs du col de l'utérus (virologie)</term><term>Vaccination ()</term><term>Vaccination (tendances)</term><term>Vaccins contre les papillomavirus (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Papillomavirus Vaccines</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Papillomavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Papillomavirus humain de type 16</term><term>Papillomavirus humain de type 18</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Human papillomavirus 16</term><term>Human papillomavirus 18</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Early Detection of Cancer</term><term>Mass Screening</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Papillomavirus Infections</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins contre les papillomavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Sensitivity and Specificity</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dépistage systématique</term><term>Détection précoce de cancer</term><term>Femelle</term><term>Humains</term><term>Infections à papillomavirus</term><term>Jeune adulte</term><term>Sensibilité et spécificité</term><term>Tumeurs du col de l'utérus</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human papillomavirus (HPV)-related screening technologies and HPV vaccination offer enormous potential for cancer prevention, notably prevention of cervical cancer. The effectiveness of these approaches is, however, suboptimal owing to limited implementation of screening programmes and restricted indications for HPV vaccination. Trials of HPV vaccination in women aged up to 55 years have shown almost 90% protection from cervical precancer caused by HPV16/18 among HPV16/18-DNA-negative women. We propose extending routine vaccination programmes to women of up to 30 years of age (and to the 45-50-year age groups in some settings), paired with at least one HPV-screening test at age 30 years or older. Expanding the indications for HPV vaccination and much greater use of HPV testing in screening programmes has the potential to accelerate the decline in cervical cancer incidence. Such a combined protocol would represent an attractive approach for many health-care systems, in particular, countries in Central and Eastern Europe, Latin America, Asia, and some more-developed parts of Africa. The role of vaccination in women aged >30 years and the optimal number of HPV-screening tests required in vaccinated women remain important research issues. Cost-effectiveness models will help determine the optimal combination of HPV vaccination and screening in public health programmes, and to estimate the effects of such approaches in different populations.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Mexique</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Slovénie</li><li>Suède</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>Champagne-Ardenne</li><li>Grand Est</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Piémont</li><li>Rhône-Alpes</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li><li>Victoria (État)</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Bruxelles</li><li>Copenhague</li><li>Londres</li><li>Lyon</li><li>Melbourne</li><li>Reims</li><li>Stockholm</li><li>Turin</li></settlement><orgName><li>Université de Londres</li><li>Université de Melbourne</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name></region><name sortKey="Bruni, Laia" sort="Bruni, Laia" uniqKey="Bruni L" first="Laia" last="Bruni">Laia Bruni</name><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><name sortKey="Diaz, Mireia" sort="Diaz, Mireia" uniqKey="Diaz M" first="Mireia" last="Díaz">Mireia Díaz</name><name sortKey="Robles, Claudia" sort="Robles, Claudia" uniqKey="Robles C" first="Claudia" last="Robles">Claudia Robles</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Arbyn, Marc" sort="Arbyn, Marc" uniqKey="Arbyn M" first="Marc" last="Arbyn">Marc Arbyn</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Baussano, Iacopo" sort="Baussano, Iacopo" uniqKey="Baussano I" first="Iacopo" last="Baussano">Iacopo Baussano</name></region><name sortKey="Clavel, Christine" sort="Clavel, Christine" uniqKey="Clavel C" first="Christine" last="Clavel">Christine Clavel</name></country><country name="Italie"><region name="Piémont"><name sortKey="Ronco, Guglielmo" sort="Ronco, Guglielmo" uniqKey="Ronco G" first="Guglielmo" last="Ronco">Guglielmo Ronco</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Dillner, Joakim" sort="Dillner, Joakim" uniqKey="Dillner J" first="Joakim" last="Dillner">Joakim Dillner</name></region></country><country name="Finlande"><noRegion><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Petry, Karl Ulrich" sort="Petry, Karl Ulrich" uniqKey="Petry K" first="Karl-Ulrich" last="Petry">Karl-Ulrich Petry</name></noRegion></country><country name="Slovénie"><noRegion><name sortKey="Poljak, Mario" sort="Poljak, Mario" uniqKey="Poljak M" first="Mario" last="Poljak">Mario Poljak</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Kjaer, Susanne K" sort="Kjaer, Susanne K" uniqKey="Kjaer S" first="Susanne K" last="Kjaer">Susanne K. Kjaer</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Meijer, Chris J L M" sort="Meijer, Chris J L M" uniqKey="Meijer C" first="Chris J L M" last="Meijer">Chris J L M. Meijer</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name></region></country><country name="Mexique"><noRegion><name sortKey="Salmer N, Jorge" sort="Salmer N, Jorge" uniqKey="Salmer N J" first="Jorge" last="Salmer N">Jorge Salmer N</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cuzick, Jack" sort="Cuzick, Jack" uniqKey="Cuzick J" first="Jack" last="Cuzick">Jack Cuzick</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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